Thursday, June 24, 2010

How an infertility drug increases the risk of birth defects

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24 June 2010

UK Edition

Dear Reader,

Desperate to conceive a child, they trust their doctors to give them the best possible treatment and guidance.

Instead, three out of 10 women seeking help for infertility are given a drug that's linked to a THREE-FOLD increase in the risk of birth defects.

Yes - an infertility treatment that evidence suggests puts the unborn child in harm's way.

Are you outraged? I know I am. I think of my friends who have struggled to start families, of countless women who have been given hope, only to face heartbreak as they find their babies have birth defects.

How in the world does something like this happen?

The drug Femara (letrozole) is intended for the treatment of breast cancer in post-menopausal women. It has NOT been approved as a treatment for infertility.

The American Food and Drug Administration (FDA) even classifies the drug as posing a pregnancy risk.

Sure, it's been studied as an infertility treatment, but there hasn't been enough evidence that shows it's safe and effective. But there's one thing there IS evidence of - a Canadian study in 2005 (2005! How many women have taken this drug in the five years since that study was conducted?) found nearly a three-fold increase in the risk of birth defects in a group of babies born after treatment with letrozole. Based on that study, doctors have been warned against using letrozole to treat infertility.

Still, a shocking 30 per cent of women being treated for infertility are unknowingly given what might as well be poison by their doctors. "Off-label" use strikes again!

There are enough potential risks associated with using drugs to treat the conditions for which they're intended. But a whole new can of worms is opened once we start spiralling out with "it might work for this" and "oh, hey, let's try it for that." We're talking about a drug that nobody's been able to show actually has anything to do with treating infertility. But, hey, these women are desperate, right? They're the perfect guinea pigs. It's disgusting.

Once a drug is approved by the FDA, doctors can basically use them for whatever they want to. And even faced with the results of the Canadian study, some doctors are saying they'll still prescribe it.

Doctors at one clinic in Chicago, in the US, use it to treat women with ovulation problems. They say the Canadian study was too small and flawed. Okay, but what about the fact that it hasn't been proven effective AND has been classified as posing a pregnancy risk?

Why in the world would you give a woman who wants to become pregnant a drug that introduces risk into that potential pregnancy? Can someone please explain this to me?

In the meantime, all we can do is spread the word. Do you know a woman who is trying to get pregnant? Please share this with her. And, as always, ask lots of questions in the doctor's office. If you have to be put on a drug, ask about the evidence behind it. If you don't get an answer that satisfies you, it's time to make a choice.

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The truth behind heartburn

Q: I know from reading your newsletter that heartburn is usually caused by a lack of stomach acid, rather than too much. Do low levels of stomach acid cause any other problems in the body?

Dr. Jonathan V. Wright: To save space, I'll just make a list of some of the numerous conditions linked to (and made worse by) low stomach acid:

Acne rosacea, physical signs of ageing (especially in people 60 and older), allergies, alcoholism, coeliac disease, childhood asthma, hepatitis, hives, depression, dermatomyositis, diabetes (Type 1), eczema, gallbladder disease, Graves' disease, lupus, macular degeneration, multiple sclerosis, myasthenia gravis, osteoporosis, pernicious anaemia, polymyalgia rheumatica, Raynaud's syndrome, rheumatoid arthritis, scleroderma, Sjogren's syndrome, ulcerative colitis, and vitiligo.

And there are probably many more. Of course, poor stomach function isn't the sole or even the major cause of each of these diseases. But taking the appropriate steps to eliminate hypochlorhydria (insufficient stomach acid production) and, in the process, restoring optimal nutrient flow usually makes a significant improvement, no matter what the problem.
Bear in mind we are not addressing anyone's personal situation and you should rely on this for informational purposes only. Please consult with your own doctor before acting on any recommendations contained herein.

Wishing you the best of health,

Andrew Miller
UK Editor


P.S. In the latest issue of Nutrition & Healing, Dr Jonathan V. Wright uncovers the stunning truth behind a so-called 'essential vitamin'. Discover how mainstream medicine has been misleading you by advising you to take folic acid supplements… and the simple switch that can really benefit your health. Also, learn about the overlooked blood test that could be key to your good health. Plus, a closer look at the amazing cover-ups aiming to destroy herbal medicine.

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Sources:

"Breast cancer drug often given for infertility," Reuters (www.reuters.com)

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