Friday, July 23, 2010

Statin controversy: results of major statin trial are biased and flawed

You are receiving this e-mail because you subscribed to The Daily Health on 2010-06-04 00:00:00

If you have not already done so, please confirm your subscription here.

Click the link if you'd like to unsubscribe from The Daily Health

(images are being blocked) HSI e-Alert UK Edition

DAILY HEALTH RECOMMENDS
NO MORE UNSIGHTLY, UNWANTED HAIR
No pain, no mess, no allergic skin reactions, no cuts and nicks – just silky smooth skin up to 10 times cheaper than normal treatments...
with this new breakthrough technology

MEET THE DOCTOR WHO'S SAVING NATURAL MEDICINE
. . . and help you stay FREE from most of the crippling, life-threatening illnesses we suffer today...
All this from one of the world's greatest pioneers of natural medicine
CLAIM YOUR FREE 7-VOLUME LIBRARY OF NATURAL HEALING HERE

63 BREAKTHROUGH Arthritis Solutions
...Your doctor won't tell you about this!

.. A groundbreaking research report that will help you put an end to your arthritis pain...

.. STOP suffering from Arthritis pain today
Order your report here and enjoy a privileged one-time-only 50% discount on the full price.

In Today's Issue

23 July 2010

  • 63 BREAKTHROUGH Arthritis Solutions... you won't hear about from your doctor
  • Statin controversy: results of major statin trial are biased and flawed

  • Drop your blood pressure 9.1 points in 28 days...


63 BREAKTHROUGH Arthritis Solutions... You Won't Hear About From Your Doctor

This groundbreaking research report will help you put an end to your arthritis pain and also help you to discover:

# A breakthrough in electro-magnetic pain relief technology kept secret for 60 years (page 16)

# A 1,000 year old Ayurvedic medicine that improves joint pain, swelling and morning stiffness for 97 per cent of patients (page 18)

# The spiky leaves of a rainforest plant that reduce pain by up to 70 per cent for rheumatoid arthritis sufferers (page 18)

# From the HSI Case Study files: The rose hip remedy that can improve arthritis symptoms in as little as 3 weeks (page 20)

# 'Nature's aspirin' - the natural medicine made from tree bark that's safer and more effective than NSAIDs

# The 10-herb compound that not only reduces joint inflammation, but can also protect your prostate.

Plus more . . . Much more . . . And all explained in no-nonsense, jargon-free language

STOP suffering from Arthritis pain today and order the '63 BREAKTHROUGH Arthritis Solutions'. You will also get a privileged one-time-only 50% discount on the full price.

Click here to learn more:

Statin Controversy: Results of Major Statin Trial are Biased and Flawed

Dear Reader,

Almost two years ago, when the results of JUPITER (Justification for the Use of Statins in Primary Prevention) were released singing the praises of cholesterol-lowering statins, the Daily Health was one of the first to call its findings into question.

Along with the fact that there are nearly 900 clinical trials citing the adverse side effects of statins, we also questioned the fact that JUPITER was funded by the manufacturers of Crestor (the popular statin drug used in the trial), AstraZeneca...

Two years later and the medical mainstream have finally caught onto our way of thinking...

A bit of background

JUPITER, a two year study, involved 18,000 patients and was designed to see if Crestor reduced heart attacks and strokes in patients with high inflammation in the blood stream, but with low-to-normal cholesterol levels.

The trial ended early when a provisional analysis showed a 44 per cent reduction in the risk factors... The logic probably was that with results that positive, why continue the study?

Back then, the final published results showed that statin (Crestor) use reduced heart attacks by 54 per cent, strokes by 48 per cent and the need for a bypass by 46 per cent, compared with a placebo...

Now, according to an article in the Archives of Internal Medicine, researchers who took a second look at the findings of JUPITER say that the results are flawed.

From the same hymn-sheet

Dr. Michel de Lorgeril, of Joseph Fourier University and the National Centre of Scientific Research in Grenoble, France, argues that there are major discrepancies between the reductions in non-fatal stroke and heart attacks reported by JUPITER and the results of numerous other similar research trials...

According to de Lorgeril, the JUPITER results are clinically inconsistent and should not be used to change medical practice or clinical guidelines.

Just as we did two years ago, de Lorgeril and his team also question AstraZeneca's involvement in the trial. In their article, the researchers point out that 9 of the 14 researchers in the JUPITER trial have financial relationships with AstraZeneca...

Dr. de Lorgeril also cited the early termination of JUPITER as one of several methodological problems with the trial.

In many clinical trials, there are pre-specified early stopping points which are clearly described in the trial protocol. However, this was not the case in the published description of JUPITER's protocol...

This leaves the question: which endpoint was used to define the rules for stopping, or which level of benefits was required to justify early termination?

It also makes one wonder if, along with a vested interest and financial incentives, the JUPITER researchers ran the trial until they had the outcome they were looking for...

To date JUPITER stands alone in its finding of showing a significant benefit of statin use in patients with no history of coronary heart disease (CHD).

Based on their review, Dr. de Lorgeril says that the time has come for a critical reappraisal of cholesterol-lowering statin treatments in the prevention of CHD. He added that the emphasis on statin use for the prevention of CHD takes the attention away from the proven benefits of adopting a healthy lifestyle, including regular physical activity, not smoking, and a Mediterranean-style diet.

Insult to injury

In the same issue of the Archives of Internal Medicine, another article supports Dr. de Lorgeril's take on the JUPITER findings.

A meta-analysis - reviewing 11 randomized clinical trials to see if statins cut death rates among intermediate and high- risk patients with no history of CHD - found no evidence that statins are associated with a reduced risk of death among those at risk.

The study, involving a total of 65,229 patients, was led by Dr. Kausik Ray of the University of Cambridge. Dr. Ray concluded that due consideration is needed in applying statin therapy in lower-risk primary prevention populations.

However, based on the findings we'd argue that this applies to high-risk patients too!

This, along with the dangerous side effects of statins, like muscle problems, anaemia, sexual dysfunction, pancreas or liver dysfunction, and cataracts, puts a massive question mark over any potential benefits of using them.

Continues below...

Drop your Blood Pressure 9.1 points in 28 Days...


Anti-hypertension drugs are waging chemical warfare on your body, but this clinically tested, non-aggressive, 100% all natural product lowers systolic blood pressure by 10.6 points and diastolic blood pressure by 9.3 points in just weeks...

AND

It's triple 'halo' effect keeps on protecting you...

*** maintaining healthy blood pressure,

*** protection against heart attack and stroke,

*** and the peace of mind that you're not corroding your stomach or damaging your body with risky prescription drugs

Claim your risk-free, 30 Day Home-Trial here

...and another thing

Chronic back pain is often due to poor posture, injuries, or muscle tension, and can profoundly impact your quality of life.

Instead of using medications to dull the pain, try yoga. This proactive approach can help prevent further injury and lessen the symptoms of current back pain.

Yoga can:

* Engage your body, mind and spirit, which may lead to a feeling of self-reliance and control over your pain.

* Provide long-term preventive relief, through improved posture, breathing techniques, and stress reduction.

* Make you more aware of your body - balance, posture and proper alignment will be a renewed focus in your life.

* Strengthen your abdominal and leg muscles and increase blood flow - all of which can be beneficial for the back.

* Soothe your mind, which in turn can produce a relaxed, calm and meditative state that can lessen pain.

Until next time,

Francois Lubbe
UK Editor


P.S. This month's Health Sciences Institute (HSI) newsletter will tell you about the astonishing nutrient that heralds a major breakthrough in the fight against Alzheimer's. You'll also discover the revolutionary new formula that helps tackle the cause of arthritis… it can even halve pain levels in some cases. Plus we'll give you full details about the ancient Chinese secret that helps banish wrinkles and rejuvenates your skin from the inside out.

All new members who sign up to the Health Sciences Institute will receive the latest issue of HSI along with a FREE encyclopaedia, HSI's 100 Greatest Underground Cures... Soon you'll discover why our premium members believe HSI is the ultimate resource for anyone seeking a better, newer solution to their health problems.

Click here for full details.
Sources:

Cholesterol-Busting Statins: Study Raises New Concerns, published online 29.06.10, abcnews.go.com

Report Examines Whether Statins Prevent Death in High-Risk Individuals Without Heart Disease, published online 04.07.10, sciencedaily.com

Cholesterol Lowering, Cardiovascular Diseases, and the Rosuvastatin-JUPITER Controversy, published 28.06.2010, Arch Intern Med

Customer reference number: 000052221104

You are receiving this email because you have given us permission to contact you. Agora Health Ltd presents information and research which is believed to be reliable, but its accuracy cannot be guaranteed. All material in this email alert is provided for information only and may not be construed as medical advice or instruction. No action or inaction should be taken based solely on the contents of this email alert; instead readers should consult their family doctor and other qualified health professionals on any matter relating to their health and well-being. The information and opinions provided in this email alert are believed to be accurate and sound, based on the best judgement available to the authors. Readers who fail to consult with appropriate health authorities assume the risk of any injuries. The publisher is not responsible for errors or omissions.

(images are being blocked) The Healthier Life Want more?

Visit The Healthier Life website.

To get the very latest breakthrough treatments that are achieving remarkable success

To share your views with our online community or ask a question in our Health Forum

Query?

Please do not reply to this email. Messages to the HSI sending address will not be seen by customer services. All correspondence should be sent to dailyhealth@agorapub.co.uk

Thank you for all your emails which have been flooding in. Here at Agora Health Ltd we aim to answer as many of your queries as possible. However, due to the sheer volume of queries we are now receiving each day we cannot guarantee an individual answer to every query. For this reason we will aim to address your queries and health concerns through the e-alert itself rather than individually.

Know someone who'd love to receive the HSI e-alert themselves?

Know someone who'd like to receive HSI Daily Health E-alert themselves?
Simply forward the following link to anyone you think could benefit from our free daily service:

http://signup.healthsciencesinstitute.co.uk/dh1.php?x=XHDHD702


To end your subscription please click here


If you do not wish to click on the unsubscribe link, please call our Customer Services department, and one of our representatives will be happy to unsubscribe you. The number to call is 0207 633 3655 between 9.00am-5.30pm, Monday to Friday.

(images are being blocked) Agora Inc. Sun Logo thehealthierlife.co.uk | Health Archives | Health Forum | Whitelisting Copyright 2010. All Rights Reserved. The content of this site may not be redistributed in any way with out written consent of Agora Inc.

No comments:

Post a Comment

Counter

Search This Blog

Blog Archive