Thursday, August 26, 2010

Over-the-counter weight loss drug linked to severe liver injury

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26 August 2010

UK Edition

Dear Reader,

I'm ignoring the swimming trunks in the bottom of my chest of drawers and I'm pretending that it's not August and time for pool parties and beach outings...

Like many people, I've put on a little "hibernation" weight during the winter. And like many people, I'm wishing I had just a little bit more time to shed it before swimming trunk season is over... so that I can actually say I wore my swimming trunks at least once...

So what will I do now? Drive to the chemist and grab a box of Alli? Ask my doctor for a prescription for Xenical (both containing orlistat)?

Not likely, considering what I already knew about the stuff. And certainly not after reading the consumer update the American Food and Drug Administration (FDA) recently quietly released.

Almost a year ago, the FDA announced it was looking into possible connections between orlistat and liver injury. (Meanwhile, of course, people just kept taking it — why rock the Big Pharma boat?)

There hadn't been any instances of significant liver damage in preclinical or clinical trials. Is that really surprising? All of these trials are just long enough to get the results the drug companies are looking for, but never long enough to reveal anything that would keep them from getting precious FDA approval.

After releasing it on the market... well, that's a different story. Orlistat was linked to 13 cases of severe liver injury. Some patients died or needed a liver transplant.

The FDA says they can't establish a causal relationship yet, but I'm not holding my breath for them to.

In the meantime, they're just going to cover themselves by sending out a consumer update and by adding warnings to the boxes. Knowing full well that lots of desperate people out there are going to keep seeking it out.

If you're one of those people who might still be tempted by orlistat's promises of weight loss — especially with Alli so readily available over the counter — don't lose heart and keep on trying to lose weight with safer and natural ways...

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Natural help for bipolar disorder

Q: The medication my wife takes for her bipolar disorder eases her symptoms, but it also causes some unpleasant side effects. Are there any natural treatments for this condition?

Dr. Jonathan V. Wright: For those readers who may not be familiar with it, bipolar disorder, also called manic depression, is a mental illness characterized by extreme mood swings — from elation to severe depression to violent anger.

Mainstream treatment of bipolar disorder usually involves the use of anticonvulsive drugs, which have many side effects including nausea, distorted perception, and suppression of the immune system.

But there is a natural alternative that may help — one you've likely seen mentioned many times before in the e-Tips and in Nutrition & Healing: fish oil. In addition to its numerous other benefits, fish oil can also help ease bipolar disorder. In fact, the effects of fish oil for bipolar disorder have been tested in a double-blind, placebo-controlled study. The study showed that those patients taking fish oil experienced longer periods between symptoms than those taking a placebo. In addition to these promising results, the study also showed that fish oil is very safe — causing only occasional stomach irritation.

Also, always remember to take vitamin E (preferably in the form of "mixed tocopherols") whenever you take supplemental oils of any sort. Vitamin E prevents the oil from oxidizing, or becoming rancid, too quickly. It also helps your body metabolize the oil effectively.
Bear in mind we are not addressing anyone's personal situation and you should rely on this for informational purposes only. Please consult with your own doctor before acting on any recommendations contained herein.

Wishing you the best of health,

Andrew Miller
UK Editor


In the latest issue of Nutrition & Healing, Dr Jonathan V. Wright will tell you about the small fruit that could prove to be a huge threat to Big Pharma. Discover the remarkable root-plant that can bring much-needed relief from nausea for pregnant women and cancer patients. Also, learn why bacon and eggs could be your 'new' healthy breakfast.

All new members who sign up will receive important updates like these in addition to receiving Dr. Wright's 7 Volume Library of Natural Healing.

Click here for full details.

Sources:

"Weight-Loss Drugs and Risk of Liver Failure," FDA (fda.gov)

"FDA Adds Risk for Severe Liver Injury to Orlistat Label," Medscape Today (medscape.com)

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