Wednesday, August 18, 2010

Type 2 diabetes drug poses serious health risks

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18 August 2010

  • Get natural infection protection all year round
  • Type 2 diabetes drug poses serious health risks

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Type 2 Diabetes Drug Poses Serious Health Risks

Dear Reader,

The most serious danger to type 2 diabetics might not be sugar at all. It might be your medication.

The problem is metformin, a drug that's been around for decades and used by millions.

By the time the American Food And Drug Administration (FDA) finally approved metformin for use in the US in 1994, researchers were already aware the drug was linked to poor absorption of vitamin B12. Further research suggested that metformin might actually cause B12 deficiency.

Mounting health risks

And now there's important new research from the Netherlands.

After a four-year intervention, diabetic subjects who used metformin ended up with B12 levels that were nearly 20 per cent lower than the placebo group on average. Subjects in the metformin group were also at higher risk of developing a full-blown deficiency of this very important vitamin.

So what makes B12 so important?

Let's start with homocysteine. A high level of this amino acid has been linked to increased risk of dementia, Alzheimer's disease, heart attack, stroke, and Parkinson's disease. But B12 is one of the key vitamins that helps metabolize homocysteine, which drives your level down.

In the Netherlands study, homocysteine increased by an average of 5 per cent in subjects who took metformin.

B12 also plays a role in keeping your bones healthy. A University of California study found that women with the lowest levels of B12 had a significantly higher risk of bone loss and fractures compared to women with the highest levels.

Course correction

Unfortunately, the Netherlands study didn't determine if B12 supplementation would correct the deficiency. But let's assume that supplements would be helpful, at the very least, and go forward from there.

Dr. Spreen recommends 1,000 micrograms of B12 daily, taken in sublingual form (dissolved under the tongue). And he notes that of the three B12 forms, methylcobalamin is by far the best.

But he adds an important note that B12 needs other nutrients in order to be most effective.

His recommendations:

* Folate - 1.6 mg daily
* Vitamin B6 - 100 mg daily
* Magnesium - 400 to 500 mg daily

Your best dietary sources of B12 are primarily meat, fish and eggs (so vegetarians and vegans will definitely want to supplement). Folate and B6 are found in asparagus, lentils, chickpeas, most varieties of beans, and especially spinach and other leafy green vegetables. For magnesium, you want to eat plenty of avocados, nuts, seeds, whole grains, and (again) leafy green veggies.

Continues below...

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...and another thing

And today's award for talking out of both sides of your mouth goes to...the American Thyroid Association (ATA).

In a letter published in the New England Journal of Medicine, several ATA members cautioned that cutting back on salt also cuts back your intake of iodine.

Salt has been iodized in the US for nearly 90 years to prevent thyroid conditions such as goitre.

But more recently, another iodine benefit has been recognized. Researchers have found a significant link to iodine deficiency and breast cancer risk. Risk of prostate and ovarian cancers may also be linked to this deficiency.

So here's where it gets confusing: The ATA guys note in their letter that they agree with the recommendation to reduce salt intake to promote heart health...

See what I mean?

The ATA of all people should know that the iodine content in your average table salt is really minimal.

To Your Good Health,

Jenny Thompson
HSI Director


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Sources:

"Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial" BMJ, Published online ahead of print 5/20/10, bmj.com

"Low Plasma Vitamin B12 is Associated With Lower BMD: The Framingham Osteoporosis Study" Journal of Bone & Mineral Research, Vol. 20, No. 1, January 2005, jbmr-online.org

"Iodine Levels a Worry as Salt Use Declines" HealthDay News, 6/17/10, consumer.healthday.com

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